Well, coming from more "homogeneously-engineered" Japan Inc. motorcycles, years ago...Guzzis are just totally different.
Longitudinal drivetrain, shaft drive, weird wiring, kickstand, separate transmission, bevel box, dry clutch, linked braking system, I am sure there are other things that I haven't heard about yet...Guzzis are just a different kind of animal.
The only machine stranger would be an air cooled BMW boxer, or or Munch Mammut.